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The real-time neurotransmitter detection system uses fast scanning cyclic voltammetry (FSCV) technology to quickly monitor the content of catecholamine neurochemicals (such as dopamine, norepinephrine, serotonin, etc.) in animals in real time. The system uses carbon fiber biosensors to achieve short-term rapid measurements on the bodies of rats and mice.
There are two styles of the system: a wireless telemetry system for rats and a wired telemetry system for mice.
The system supporting software not only supports the traditional short-term measurement mode (recording data within 2 minutes), but also supports the extended continuous long-term recording mode. In addition, the software features include background noise cancellation, heat map, 3D visualization, optional filtering and dynamic desk map. The data can be exported as a universal Excel file. In addition, the software also supports integrated synchronous video capture, which is suitable for the simultaneous study of the relationship between animal behavior and biological material release.
Pinnacle's FAST SCAN CYCLIC VOLTAMMETRY (FSCV) SYSTEM is specifically designed to simplify the measurement of catecholamines (ie, dopamine, norepinephrine, and serotonin). Pinnacle offers turn-key systems for both mice and rats. Both the wireless rat system and the tethered mouse system use carbon fiber sensors to enable short-term measurement in the brains of freely moving animals .
HOW IT WORKS
Biogenic amine levels are detected by rapidly cycling a voltage across an implanted carbon fiber sensor and measuring the resulting current. Our systems can measure spontaneous sub-second neurotransmitter release events while conducting detailed behavioral studies. Both the wireless and tethered systems sweep from 250 to 400 V / s in a user-selectable range spanning -1.1 to +1.3 V. All systems have built-in support for controlling an external stimulus.
l Voltage Span: -1.1 V to +1.3 V
l Range: 250 – 400 V / s
l Sweeps / second: 5-10
l Points / sweep: 1000
Dopamine (blue), serotonin (green), and norepinephrine (pink) have specific voltammogram profiles when detected by FSCV.
The TETHERED FAST SCAN CYCLIC VOLTAMMETRY (FSCV) SYSTEM allows researchers to harness the powerful genetics of the mouse model to address underlying mechanisms of biogenic neurotransmitter release and function. A headmounted FSCV board sends signals through a low-torque commutator to an interface box that streams data to the host PC. The system comes with Pinnacle's FREE 8500 software.
1. The FSCV interface box provides access to stimulus lines and transmit data to PAL-8500 software.
2. A low-torque commutator, which is mounted above the cage, allows for unencumbered freedom of movement.
3. Signals are amplified and filtered at the head of the animal using our headstage, which ensures the delivery of clean, artifact-free data.
4. Stereotaxically placed guide cannulas allow easy insertion of carbon fiber sensors. Headmounts are affixed to the skull with dental acrylic and act as a connection port for the headstage.
Pinnacle's FSCV system uses CARBON FIBER SENSORS (CFSs) to measure the presence of dopamine and other catecholamines in the brains of freely moving animals. Our sensor is a 34 µm diameter carbon fiber housed in a silica sheath that extends 0.5 mm beyond the end of the silica. All Pinnacle CFSs require an Ag / AgCl reference electrode.
Our sensor is a 34 um diameter carbon fiber housed in a silica sheath that extends 0.5 mm beyond the end of the silica.
Carbon fiber sensors are ordered by cannula type and whether the researcher needs to remove them from the cannula for post-calibration. CFS-F sensors are fixed in the cannula and cannot be removed for post-calibration.
The FSCV system includes Pinnacle's FREE PAL-8500 software, which supports traditional, short recording paradigms (recordings of two minutes or less) as well as longer-term recordings that use an extended continuous mode. Furthermore, the suite supports integrated, synchronized video recording , which allows monitoring of animal behavior simultaneously with biogenic amine release.
Additional features of this software include:
• Background Subtraction
• 3D Visualization
• User-Selectable Filters
• Heat Maps
• Animated Voltammograms
• Export to Third-Party Packages
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