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Shanghai Yuyan Scientific Instrument Co., Ltd.

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Location: ⎝⎛七乐彩⎞⎠ > Pain & Inflammation Research> Plantar Pain Measuring Instrument
Pain and inflammation research

Plantar pain measuring instrument

来源:本站 作者:玉研仪器 Time: 2016-09-20 Source: Site Author: Jade research instrument

Detailed introduction

痛觉测量仪(大小鼠 足底热测痛仪 ,热刺激痛觉测试仪 , Hargreaves Method , Plantar Test Apparatus for Mice and Rats 测试大鼠和小鼠的疼痛反应时间,进行快速精确地筛选麻醉型镇痛药物,更多详情敬请来电咨询) Plantar Pain Tester ( Plant and Mouse Pain Tester , Hargreaves Method , Plantar Test Apparatus for Mice and Rats ) Type analgesics, please call for more details)


Model: 390 type, 390G type

 

实验用于测试镇痛药物影响无束缚大鼠对外部热刺激的反应时间,使用时先通过从爪下面的测试头发出导向光将光源移到动物爪底,通过反光镜确定位置,避免频繁弯腰和低头,方便操作,启动加热光束照射到动物爪底进行实验。 The plantar pain test is used to test the effect of analgesic drugs on the response time of external thermal stimuli in rats. First, the light source is moved to the bottom of the animal's paw by guiding light from the test hair under the paw. Avoid bending over and lowering your head frequently for easy operation. Start the heating beam to irradiate the animal's paw for experiment.

 

The Plantar Analgesia Meter for thermal paw can be used on 12 mice, 6 rats and other animals (cats, rabbits) unrestrained when testing for narcotic drugs. Experiments are easy to perform, simply slide the test head under test subject, align the heat source via our exclusive guide light (idle state) by the attached, adjustable, angled mirror on test head to test subject and perform tests.

 

Main features of plantar heat pain meter:  

 

精确数字控制, 时间精确度为 0.01 ØAccurate digital control, time accuracy is 0.01 seconds

自动切断保护功能 Ø Automatic cut-off protection function

光束强度可调节,步进量 1 ØBeam intensity can be adjusted, the step is 1 %

手工结束测试,减少误触发 Ø End the test manually to reduce false triggers

强制取消定时器功能 Ø Forced cancellation of timer function

数字显示功能 Ø Digital display function

动物不需固定限制 Ø Animals do not need to be fixed

加热玻璃可选配 Ø Heating glass optional

测试头具有反光镜辅助观察 Ø Test head with reflector to assist observation

标准计算机打印口输出 Ø Standard computer print port output

型号: 390 爪刺激痛觉测试仪 Ø Model: 390 claw stimulation pain tester

型号: 390G 爪刺激痛觉测试仪内置热玻璃 Ø Model: 390G claw stimulation pain tester built-in hot glass

 

Technical parameters of plantar heat pain meter:

 

可见光法测试、精确数字程控 Ø Visible light test, precise digital program control

适用于小鼠、大鼠、猫、兔等实验动物,动物无需固定全自然状态下测试 ØApplicable to experimental animals such as mice, rats, cats, rabbits, etc.

2 通道大鼠或 4 通道小鼠(最多可达 6 通道大鼠或 12 通道小鼠) Ø 2- channel rat or 4- channel mouse (up to 6- channel rat or 12- channel mouse)

刺激光可调,范围从室温 ~250℃ Ø Stimulation light adjustable, ranging from room temperature to 250 ℃

计时器精度: 0.1 Ø Timer accuracy: 0.1 seconds

按钮及脚踏开关控制启动、停止和重设实验 Ø Button and foot switch control start, stop and reset experiment

探视镜及玻璃板角度可调 Ø Viewing mirror and glass plate angle adjustable

引导光线协助定位 Ø Guide light to assist in positioning

自动断电关闭设计,人道避免动物组织损伤 Ø Automatic power off design, humane to avoid animal tissue damage

USB RS232 标准 Ø USB and RS232 standards

电压范围 120v~240V Ø Voltage range 120v ~ 240V

通过 CE 认证 Ø Passed CE certification

独家选配加热玻璃板,温度调节范围 30~40℃ Ø Exclusive optional heating glass plate, temperature adjustment range 30 ~ 40 ℃

独家选配数据采 集软件 Ø Exclusive optional data acquisition software



Some references:


Peripherally acting mu-opioid receptor agonist attenuates neuropathic
pain in rats after L5 spinal nerve injury
Y Guan, LM Johanek, TV Hartke, B Shim, YX Tao…-Pain, 2008-Elsevier
Abrupt paw-withdrawal, licking, and shaking were regarded as positive responses. To test for ... Abrupt paw-withdrawal, licking, and shaking were regarded as positive responses. To test for
signs of heat hyperalgesia, paw-withdrawal latencies (PWLs) to radiant heat stimuli [19] were
IITC model 390 , Woodland Hills, CA). ... measured with a plantar stimulator analgesia meter ( IITC model 390 , Woodland Hills, CA). ...

Sex-specificity and estrogen-dependence of kappa opioid
receptor-mediated antinociception and antihyperalgesia
KP Lawson, S Nag, AD Thompson, SS Mokha-Pain, 2010-Elsevier
2.8. Paw withdrawal assays. Thermal hyperalgesia was measured using a plantar ... 2.8. Paw withdrawal assays. Thermal hyperalgesia was measured using a plantar
IITC model 390 , Woodland Hills, CA), as described originally by analgesia meter ( IITC model 390 , Woodland Hills, CA), as described originally by
... Hargreaves [25]. Animals were placed in a clear plastic cage ...

Antinociceptive effects of MSVIII-19, a functional antagonist of the
GluK1 kainate receptor
CS Qiu, LLV Wyhe, M Sasaki, R Sakai, GT Swanson…-Pain, 2011-Elsevier
Mice were placed in individual 10 × 10 × 15-cm plastic boxes on a glass floor of the ... Mice were placed in individual 10 × 10 × 15-cm plastic boxes on a glass floor of the
390 , IITC Life Science) and allowed to acclimate for at least 30 minutes apparatus (model 390 , IITC Life Science) and allowed to acclimate for at least 30 minutes
... before drug or vehicle injection. Each paw was tested at least 3 times. ...

Low-frequency electroacupuncture suppresses carrageenan-induced paw
inflammation in mice via sympathetic post-ganglionic neurons, while
high-frequency EA…
HW Kim, DK Uh, SY Yoon, DH Roh, YB Kwon…-Brain research…, 2008-Elsevier
responses to noxious thermal stimuli, paw withdrawal latency was evaluated based on a ... responses to noxious thermal stimuli, paw withdrawal latency was evaluated based on a
previously described procedure [8]. Briefly, a radiant heat source was positioned beneath the
hind paw in thermal tester (IITC 390 plantar tester, IITC Life Science, Woodland Hills, CA USA) ...

Macrophage inflammatory protein-1α mediates the development of
neuropathic pain following peripheral nerve injury through interleukin-1
β up-regulation

N Kiguchi, T Maeda, Y Kobayashi, Y Fukazawa…-Pain, 2010-Elsevier
... 2.6. Hargreaves test. Thermal hyperalgesia was evaluated by withdrawal latency using
the IITC 390 Plantar Test Analgesia Meter (Neuroscience, Tokyo, Japan). Mice were
placed on top of a glass sheet, and covered with a clear cage. ...

CC-chemokine MIP-1α in the spinal cord contributes to nerve
injury-induced neuropathic pain
N Kiguchi, Y Kobayashi, T Maeda, F Saika…-Neuroscience…, 2010-Elsevier
... Thermal hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test
Analgesia Meter (Neuroscience). Mice were placed on a glass sheet and covered with a
clear cage. Mice were allowed to adapt for 2–3 h before the test. ...

Transient heat hyperalgesia during resolution of ropivacaine sciatic
nerve block in the rat
LM Kolarczyk, BA Williams-Regional anesthesia and pain…, 2011-ncbi.nlm.nih.gov
... min to a raised, fenestrated stainless-steel table (which provided access to the plantar aspect
of each hindpaw for application of von Frey monofilaments from below), followed by a minimum
of 5 min acclimation on a glass thermal (34 ° C) table apparatus (IITC ® 390 Plantar Test ...

Suppressive effect of imipramine on vincristine-induced mechanical
allodynia in mice
F Saika, N Kiguchi, Y Kobayashi, Y Fukazawa…-Biological and…, 2009-jlc.jst.go.jp
... before morphine administration) (value of% response at 30 min after morphine administration)] / (
value of% response before morphine administration) Thermal Paw Withdrawal Test Thermal
hyperalgesia was evaluated by withdrawal latency using the IITC 390 Plantar Test ...

CC‐chemokine ligand 4 / macrophage inflammatory protein‐1β
participates in the induction of neuropathic pain after peripheral nerve
injury
F Saika, N Kiguchi, Y Kobayashi…-… Journal of Pain, 2012-Wiley Online Library
... 2.3 Hargreaves test. Thermal hyperalgesia was evaluated by withdrawal latency
using the IITC 390 Plantar Test Analgesia Meter (Neuroscience). The mice were
placed on the top of a glass sheet and covered with a clear cage. ...

Epigenetic augmentation of the macrophage inflammatory protein 2 / CXC
chemokine receptor type 2 axis through histone H3 acetylation in injured
peripheral nerves…

N Kiguchi, Y Kobayashi, T Maeda, Y Fukazawa…-… of Pharmacology and…, 2012-ASPET
... Mice were allowed to adapt for 2 to 3 h before the test. The radiant heat source,
IITC 390 Plantar Test Analgesia Meter (Neuroscience), was positioned under the
glass sheet and applied to the plantar surface of the hind paw. ...

Activation of extracellular signal-regulated kinase in sciatic nerve
contributes to neuropathic pain after partial sciatic nerve ligation in
mice
N Kiguchi, T Maeda, Y Kobayashi…-Anesthesia &…, 2009-journals.lww.com
Advertisement. Close Window. Close Window. Enter your Email address: Wolters Kluwer Health
may email you for journal alerts and information, but is committed to maintaining your privacy
and will not share your personal information without your express consent. ...

Learning and memory with neuropathic pain: impact of old age and
progranulin deficiency
B Albuquerque, A Häussler, E Vannoni…-Frontiers in…, 2013-ncbi.nlm.nih.gov
... Heat hyperalgesia was assessed by recording the paw withdrawal latency in the Hargreaves
Test (IITC 390 Plantar Test), in which a radiant heat source is placed underneath the hind paw
with a mirror system and applies radiant heat upon pressure of a button. ...

Activation of nicotinic acetylcholine receptors on bone marrow-derived
cells relieves neuropathic pain accompanied by peripheral
neuroinflammation
N Kiguchi, Y Kobayashi, T Maeda, S Tominaga…-Neurochemistry…, 2012-Elsevier
... The radiant heat source, IITC 390 Plantar Test Analgesia Meter (Neuroscience), was
positioned under the glass sheet and applied to the plantar surface of the hind paw. Thermal
hyperalgesia was designed as the mean latency of three stimulations. ...

Epigenetic augmentation of the MIP-2 / CXCR2 axis through histone H3
acetylation in injured peripheral nerves elicits neuropathic pain
N Kiguchi, Y Kobayashi, T Maeda, Y Fukazawa…-… of Pharmacology and…, 2011-ASPET
... Mice were allowed to adapt for 2–3 h before the test. The radiant heat source, IITC 390 Plantar
Test Analgesia Meter (Neuroscience), was positioned under the glass sheet and applied to the
plantar surface of the hind paw. Withdrawal latencies were measured three times ...

A practitioner report on the evaluation of the performance of the C, C ++
and Java compilers on the OS / 390 platform
DA Cargill, M Radaideh-Performance Analysis of Systems and…, 2000-ieeexplore.ieee.org
... To do this analysis, we iise tlie pcrformnncc tools availablc on thc OS / 390 platihnn, specifically
thc PerTonnnncc Analyzcr from IBM [2] atid Strobctg ... I-Iowcver, wc realize that
cotii ~~ iitc -iiiterisivc
bcrichti ~ irks do iiot STI'CSS he opcratiiig syslcin or llic 110 siibsystciii and iiiay not bc ...

Pentoxifylline attenuates the development of hyperalgesia in a rat model
of neuropathic pain
J Liu, X Feng, M Yu, W Xie, X Zhao, W Li, R Guan…-Neuroscience…, 2007-Elsevier
... Five tests were conducted at intervals of 5 min and the force (g) applied was recorded.
Thermal sensitivity was determined by using paw withdrawal latencies to radiant
heat (Model 390, IITC Life Science, INC.). After animals ...

Effect of betamethasone on neuropathic pain and cerebral expression of
NF-κB and cytokines
W Xie, X Liu, H Xuan, S Luo, X Zhao, Z Zhou, J Xu-Neuroscience letters, 2006-Elsevier
... The threshold of paw withdrawal to noxious heat stimuli was measured using a paw stimulator
analgesia meter (Model 390, IITC Life Science, Inc.). Rats were placed on a 6-mm thick glass
floor under an inverted clear Plexiglas cage and were allowed to acclimatize for 10 min. ...

Topical application of l-menthol induces heat analgesia, mechanical
allodynia, and a biphasic effect on cold sensitivity in rats
AH Klein, CM Sawyer, MI Carstens…-Behavioural brain…, 2010-Elsevier
... A light beam (Plantar Test 390, IITC, Woodland Hills, CA) was focused onto the plantar
surface of the hind paw through the glass plate from below, and the latency from onset
of the light to brisk withdrawal of the stimulated paw was measured. ...

Behavioral evidence of thermal hyperalgesia and mechanical allodynia
induced by intradermal cinnamaldehyde in rats
MG Tsagareli, N Tsiklauri, KL Zanotto, MI Carstens…-Neuroscience…, 2010-Elsevier
... A light beam (Plantar Test 390, IITC, Woodland Hills, CA) was focused onto the plantar
surface through the glass floor from below, and the latency from onset of the light
to brisk withdrawal of the stimulated paw was measured. ...

Vascular endothelial growth factor signaling in injured nerves underlies
peripheral sensitization in neuropathic pain
Tel: 021-35183767 Http://duoyuanjx.com
N Kiguchi, Y Kobayashi, Y Kadowaki…-Journal of…, 2014-Wiley Online Library
... The mice were allowed to adapt for 2–3 h before the test. The radiant heat source,
IITC 390 Planter Test Analgesia Meter (Neuroscience), was positioned under the