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Respiration and lung function research

Multi-parameter lung function detection system

来源:本站 作者:玉研仪器 Time: 2016-09-29 Source: Site Author: Jade research instrument

Detailed introduction

肺功能检测系统 eSpira FM System

系统是 用于检测与肺功能相关的全部生理数据的大型系统,可对麻醉动物进行一系列成组实验的数据自动分析检测,包括用力肺活量相关数据的测试。 The eSpira ™ system is a large-scale system for detecting all physiological data related to lung function. It can automatically analyze and detect the data of a series of experiments on anesthetized animals, including testing of vital vital capacity related data. COPD 、肺间质疾病、肺纤维化等疾病临床前研究。 It is widely used in preclinical studies of COPD , interstitial lung disease, and pulmonary fibrosis.

eSpira™ 系统提供与人类肺功能指标一致的各种生理指标参数。 Similar to human lung function testing, the eSpira ™ system provides various physiological index parameters that are consistent with human lung function indexes. / 豚鼠以及其他大型动物。 The system can be used in mice, rats / guinea pigs, and other large animals. The system is highly automated and provides a wealth of icons for analysis and research.


The main detection parameters of multi-parameter lung function detection system:

用力呼气量 Forced Expiratory Volume (FEV) Forced Expiratory Volume (FEV)

肺总量 Total Lung Capacity Total Lung Capacity

用力肺活量 Forced Vital Capacity · Forced Vital Capacity

最大呼气流量 Peak Expiratory Flow Peak Expiratory Flow

最大呼气中段流量 Maximum Mid Expiratory Flow Maximum Mid Expiratory Flow

准静态压力容积曲线 Quasistatic Pressure Volume Curves Quasistatic Pressure Volume Curves

功能残气量 FRC · Functional residual gas volume FRC

阻力 / 顺应性 Resistance/Compliance Resistance / Compliance

Explanations and more parameters · Explanations and more parameters

 

Multi-parameter lung function detection system Product main features:

适用于各种实验动物:小鼠、大鼠、豚鼠、犬、灵长类动物 · Applicable to various experimental animals: mice, rats, guinea pigs, dogs, primates

经典的 肺量测定法 spirometry 检测肺功能 · Classic spirometry to detect lung function

综合的肺功能分析 · Comprehensive lung function analysis

COPD 及肺间质疾病研究的必备工具; · Essential tools for COPD and pulmonary interstitial disease research;

在数分钟内测定 FEV(x) FEF(x) FVC FRC FEVpef MMEF 等参数; · Measure FEV (x) , FEF (x) , FVC , FRC , FEVpef , MMEF and other parameters within minutes ;

气道阻力和肺顺应性直接生理数据检测; · Direct physiological data detection of airway resistance and lung compliance;

· The software automatically generates a printable data report.




eSpira FM System for Mouse

Spirometry is the most common method for assessing lung function within the clinical environment, with FEV1 (Forced Expiratory Volume in one second), in particular, being the most characterised and utilised tests. Until recently, this method of assessing lung function was precluded within the laboratory, as it involved voluntary manoeuvres. However, the EMMS eSpira? system enables a researcher to perform classical spirometry lung function testing on anaesthetised animals.

Typically, animals are intubated or tracheostomised and cannulated. The animal's lungs are inflated to a set tracheal pressure, and then exposed to a large negative pressure reservoir. This forces the subject to exhale as quickly as possible and enables the scientist to mimic classical clinical spirometry . Parameters calculated include Forced Expiratory Volume (FEVx), where x is the time in milliseconds, Forced Vital Capacity and maximum mid expiratory flow, which gives an average flow over the middle part of the flow volume curve and is useful for determining mild to moderate airway obstruction.


The graph above illustrates data obtained using the eSpira system in a chronic murine model of asthma. Mice were sensitised with Ovalbumin and challenged on multiple occasions. Control animals were injected with alum only and were administered a saline aerosol. The lung function measurements were performed 24 hours after the last challenge. There was a 49% reduction in Forced Vital Capacity (FVC) and a 46% reduction in Forced Expiratory Volume in 50 milliseconds (FEV50). These data illustrate that the eSpira? system is capable of detecting lung function changes , in a murine asthma model, similar to those observed in the clinical environment.

 

Parameters Measured Include:

Forced Expiratory Volume (FEV) Forced Expiratory Volume (FEV)

Total Lung Capacity Total Lung Capacity

Forced Vital Capacity Forced Vital Capacity

Peak Expiratory Flow Peak Expiratory Flow

Maximum Mid Expiratory Flow Maximum Mid Expiratory Flow

Quasistatic Pressure Volume Curves Quasistatic Pressure Volume Curves

FRC · FRC

Resistance/Compliance Resistance / Compliance

Explanations and more parameters · Explanations and more parameters

 


Features

Available for all common species from mouse to primate Available for all common species from mouse to primate

Replicates classical spirometry lung function testing Replicates classical spirometry lung function testing

Comprehensive lung function analysis Comprehensive lung function analysis

 

Uses

Acute and Chronic models Acute and Chronic models

Recovery anaesthesia protocols Recovery anaesthesia protocols


To detect airway resistance in small animals, select:

气道阻力和肺顺应性检测系统 Small animal airway resistance and lung compliance detection system


For non-invasive testing of lung function parameters in small animals, select:


Whole body plethysmograph



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