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全身体积描记器- 无创肺功能检测系统 Whole body plethysmography-Non-invasive lung function detection system
The Whole Body Plethysmograph System is used to measure various lung function parameters of animals when they are awake and unrestrained. This system is simple, easy to use, fast, and has a large amount of data output, which makes it a favorite research tool for foreign pharmaceutical companies' R & D institutions. It is mainly used for rough screening experiments in the development of new drugs such as asthma. Its index parameters can well reflect the airway high response of animals to drugs, which is suitable for research and long-term follow-up experiments that require animals to breathe in a natural state.
雾化攻击 、温湿度补偿接口，另外还具有供水接口和气体采样接口以适用于各种特殊需要的研究。 Each body imaging box is equipped with an atomization attack , temperature and humidity compensation interface, and also has a water supply interface and a gas sampling interface to suit various special needs research.
全身体积描记器的主要 The main of WBP whole body plethysmograph working principle:
WBP mainly detects changes in "box flow" data caused by changes in airflow caused by nasal airflow and chest and abdominal breathing movements in animals, and calculates various index parameters with reference to temperature, humidity and pressure data.
(methacholine,Mch)或生理盐水(NS)等通过雾化器雾化入体描箱内，箱内动物吸入雾化气体后呼吸运动的改变引起箱内压力、流量产出相应的变化， 连接于体描箱的压力传感器 (流量传感器)将采集到的信号传至信号处理系统，并在信号放大器作用下转化为呼吸动力学各指标值。 The methacholine (Mch) or physiological saline (NS) is atomized into the body tracing box through a nebulizer. The change in breathing movement after the inhalation of the nebulized gas in the animal in the box causes the corresponding pressure and flow in the box to produce The pressure sensor (flow sensor) connected to the body imaging box transmits the collected signal to a signal processing system, and is converted into various values of respiratory dynamics by the signal amplifier.
The whole body plethysmography system can be connected to 6 individual tracing boxes at the same time, and the corresponding sensors can simultaneously transmit the changes in pressure and flow in each box to the signal processing system for processing, so it can simultaneously perform lung function detection for multiple experimental animals.
Small animal whole body plethysmograph main feature:
适用于小鼠、大鼠、豚鼠 Suitable for mice, rats, guinea pigs
无需手术，动物处于清醒的自由活动状态； · No need for surgery, animals are awake and freely moving;
实时监测潮气量，并有多个因素补偿（如Epstein & Epstein, Drorbaugh & Fenn) Real-time monitoring of tidal volume and compensation with multiple factors (such as Epstein & Epstein, Drorbaugh & Fenn)
数据结果不受麻醉和身体创伤的副作用影响； Data results are not affected by the side effects of anesthesia and physical trauma;
实时环境监测（气压、温度、湿度） · Real-time environmental monitoring (barometric pressure, temperature, humidity)
可长达数月对同一只动物重复实验，是长期跟踪研究的理想方式； · Repeatable experiments on the same animal for months, ideal for long-term follow-up studies;
允许单一实验持续数小时至数天； Allow a single experiment to last for hours to days;
可同时对6只动物进行检测，是进行筛选实验的良好选择； · Six animals can be tested at the same time, which is a good choice for screening experiments;
可进行雾化给药（气雾攻击）； · Can be sprayed (aerosol attack);
实验操作简单易行； Simple and easy experimental operation;
可灵活与其它实验设备或方法联合使用 Flexible use with other experimental equipment or methods
The mains of whole body plethysmograph Application direction:
气道高反应模型Airway hyper-reactivity models Airway hyper-reactivity models
迟发相反应研究(late phase response,LPR) Late phase response studies Late phase response (LPR) Late phase response studies
慢性疾病研究Chronic studies · Chronic studies
药物筛选Drug screening · Drug screening
毒理学Toxicology · Toxicology
bias airflow supplies , CO2 levels, temperature and humidity are maintained at normal levels enabling measurements to be made over several hours. Whole body plethysmography is an application thereby ventilatory parameters are measured while the subject is conscious and unrestrained. By the use of bias airflow supplies , CO2 levels, temperature and humidity are maintained at normal levels enabling measurements to be made over several hours.
plethysmograph due to increased temperature and humidity of the air as it enters the subject's lungs (gas conditioning). During normal breathing, this pressure difference is directly proportional to the respiratory pattern of the subject, allowing the researcher to measure respiratory rate and tidal volume, in accordance with ICH S7 Guidelines. During inspiration there is a slight net pressure rise within the plethysmograph due to increased temperature and humidity of the air as it enters the subject's lungs (gas conditioning). During normal breathing, this pressure difference is directly proportional to the respiratory pattern of the subject, allowing the researcher to measure respiratory rate and tidal volume, in accordance with ICH S7 Guidelines.
The system is commonly used in where, in addition to changes in ventilatory parameters, valuable data can obtained airway hyper-reactivity studies where, in addition to changes in ventilatory parameters, valuable data can obtained
respiratory waveform, eg, Penh. However, it should be noted that when bronchoconstriction is present, by quantifying changes in the shape of the respiratory waveform, eg, Penh. However, it should be noted that when bronchoconstriction is present,
the respiratory signal is dominated by the effects of gas compression and therefore exact measures of tidal volume can not be determined.
Breathing frequency Breathing frequency
Tidal volume (during normal breathing) Tidal volume (during normal breathing)
Minute volume · Minute volume
Penh (enhanced pause) Penh (enhanced pause)
Inspiration time · Inspiration time
Expiration time Expiration time
Peak inspiratory flow Peak inspiratory flow
Peak expiratory flow Peak expiratory flow
Explanation and more parameters · Explanation and more parameters
Non-invasive · Non-invasive
Real time tidal volume measurement using multiple compensation factors (eg Epstein & Epstein, Drorbaugh & Fenn) Real time tidal volume measurement using multiple compensation factors (eg Epstein & Epstein, Drorbaugh & Fenn)
Real time environmental monitoring (atmospheric pressure, temperature, humidity) Real time environmental monitoring (atmospheric pressure, temperature, humidity)
Subject is unrestrained and conscious Subject is unrestrained and conscious
No anaesthesia · No anaesthesia
Range of species including guinea pigs, rats and mice Range of species including guinea pigs, rats and mice
Chronic and long term use Chronic and long term use
Measurement during aerosol challenge Measurement during aerosol challenge
Up to sixteen animals measured simultaneously Up to sixteen animals measured simultaneously
Optional body temperature measurement through telemetry · Optional body temperature measurement through telemetry
Airway hyper-reactivity models Airway hyper-reactivity models
Late phase response studies Late phase response studies
Chronic studies Chronic studies
Drug screening Drug screening
Toxicology · Toxicology
To detect airway resistance in small animals, select:
气道阻力和肺顺应性检测系统 Small animal airway resistance and lung compliance detection system
To detect more lung function parameters, you can choose:
肺功能检测系统 Multi-parameter lung function detection system