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Physiological signal measurement

Rat. Mouse Noninvasive Blood Pressure Meter MRBP

来源:本站 作者:玉研仪器 Time: 2016-09-29 Source: Site Author: Jade research instrument

Detailed introduction

系统 (适合对大鼠小鼠进行无创式的血压测量,通过对鼠尾根部的实时检测,精确测量出大鼠、小鼠的 收缩压、舒张压、平均压、心率 ,敬请来电咨询) Non-invasive blood pressure measurement system for rats and mice (suitable for non-invasive blood pressure measurement in rats and mice. Through real-time detection of rat tail roots, accurate measurement of systolic pressure, diastolic pressure, average pressure, heart rate of rats and mice , Please inquire)


生命科学仪器公司成立于 1973 年,其血压测量系统应用于全球的生命科学研究领域,经过不断的改进和拓展无创血压测量系统和测痛产品系列,其产品已用于全球实验室,也被数千篇国际论文所引用。 The United States IITC Life Sciences Instrument Company was founded in 1973. Its blood pressure measurement system is used in the field of life science research worldwide. After continuous improvement and expansion of non-invasive blood pressure measurement systems and pain measurement products, its products have been used in global laboratories, but Cited by thousands of international papers.

血压测量系统能够测量最少一只,最多同时 200 只动物,是经过验证的非常有效的手段和数据采集法,可以切实协助研究人员快速准确的在最低的推荐温度下对动物进行血压测量。 The MRBP blood pressure measurement system can measure at least one animal and a maximum of 200 animals at the same time . It is a proven and effective method and data acquisition method that can help researchers quickly and accurately perform blood pressure measurements on animals at the lowest recommended temperature.


系统的 主要优势及特点: The main advantages and characteristics of non-invasive blood pressure measurement systems for rats and mice :


仅有的可测量从小鼠、大鼠、豚鼠到猴的血压设备 Ø The only device that can measure blood pressure from mice, rats, guinea pigs to monkeys

采用光电传感技术测量原理,适用于麻醉、清醒状态下的动物血压测量 ØUsing photoelectric sensing technology measurement principle, suitable for animal blood pressure measurement under anesthesia and awake state

内置软件,通过触摸操作屏控制,操作方便。 Ø Built-in software, controlled by touch operation screen, easy to operate. It can also be controlled by computer.

测量参数:收缩压、舒张压、平均压、心率等 Ø Measurement parameters: systolic pressure, diastolic pressure, average pressure, heart rate, etc.

充放气速率1-10 mmHg/ 秒可调 Ø Filling and deflating rate 1-10 mmHg / s adjustable

自动充放气,尾套气压限值和测试截止压力值均可调,提高测试效率 ØAutomatic filling and deflating, both the tail gas pressure limit and the test cut-off pressure value can be adjusted to improve the test efficiency

血压测量范围:0-300mmHg ,精确度 ±5mmHg Ø Blood pressure measurement range: 0-300mmHg , accuracy ± 5mmHg

心率测量范围:0-1000 bpm Ø Heart rate measurement range: 0-1000 bpm

液晶屏实时显示参数测量值和脉搏波形, 并能存储、编辑、打印数据 Ø Real-time display of parameter measurement values and pulse waveforms on the LCD screen, and storage, editing, and printing of data

USB 直接储存数据功能 Ø USB direct data storage

可一次性独立或同时测试多至200 只动物 Ø Can test up to 200 animals independently or simultaneously at one time

适用于核磁共振条件(MRI Ø Suitable for magnetic resonance conditions (MRI )


特色: Main features of MRBP sphygmomanometers for rats and mice :

Non-invasive blood pressure experiments need to increase the temperature of the surroundings of the subject. Theoretically, the measurement of blood pressure works well at higher temperatures. We can control the body temperature of rats and mice by controlling the blood volume of rat tail. When the body temperature is higher than normal, the blood flowing through the tail of the mouse will dissipate excess heat. The higher the temperature, the more blood flows through the tail. 摄氏度、小鼠温度高于 34 摄氏度时,会产生热应力,动物的热量就会损失一部分。 Studies have found that when the temperature of heated rats is higher than 32 degrees Celsius and the temperature of mice is higher than 34 degrees Celsius, thermal stress will be generated, and the animal's heat will be lost. +/-12-28 mmHg This affects the true blood pressure value (changed by almost +/- 12-28 mmHg )


The form of the detection pulse is very important, and the choice of sensor determines the manufacturing process. Piezo sensors have been widely used in microphones and touch switches for many years. The principle is: after applying external force to the sensor, an electrical signal is generated. )。 But using this kind of sensor as a detection pulse has a series of problems and defects: there is a higher temperature requirement (36-40 ° C ) when performing blood pressure measurement .

),而且加热尾部是基于 尾部脉搏是局部加热的结果 这一错误的假设。 The pulse detector made of crystal also has some problems and defects: the temperature required for blood pressure measurement in rats is higher than the thermodynamic level temperature (36-40 ° C ), and the tail is heated based on "the tail pulse is locally heated " Wrong result " .


IITC 发明了光电传感器,它将光和图片传感器用于脉搏的测量。 In 1978 , the IITC invented the photoelectric sensor, which uses light and picture sensors for pulse measurement. When the blood flow passes through the tail, the change in the diameter of the tail vessel changes the amount of light, which directly leads to the change in the amount of light. 原件的设计(感应电子设备和咬合袖带)不会像其他仪器一样,会对鼠尾产生机械性的作用力,同时如果需要可以精确地切断传感器。 The design of the original IITC (inductive electronics and bite cuff) will not exert mechanical force on the mouse tail like other instruments, and can accurately cut off the sensor if necessary. 28℃ ,大鼠甚至更低。 The photoelectric sensor can detect at a closed room temperature. In fact, in many papers published using this product, the starting temperature of the mouse is lower than 28 ℃ , and the temperature of the rat is even lower.


Compared with other high temperature methods:

温度调节 Rodents, like other animals, have an internal regulation mechanism, which we call " temperature regulation . " 26-27℃ ,如果环境温度高于正常温度( 28-30℃ ), 温度调节 开始增加血液流量。 The normal ambient temperature is about 26-27 ° C. If the ambient temperature is higher than the normal temperature ( 28-30 ° C ), " temperature regulation " starts to increase blood flow. This will lead to more blood flow in the tail. Since the tail is part of the body and not simply covered by leather, it will cool itself to dissipate heat as soon as possible. This is how the blood pressure is measured indirectly.

血压计 最大的不同在于脉搏探测器上。 The biggest difference between MRBP sphygmomanometers for rats and mice is the pulse detector. 或者更低的温度下进行测量。 It can measure at 26 ° C or lower. Other pulse detectors require higher temperatures because they are not sensitive enough. Excessive temperatures can greatly increase the risk of animal death.


Some references for non-invasive blood pressure monitors for rats and mice:

Geraniol improves endothelial function by inhibiting NOX-2 derived oxidative stress in high fat diet fed mice

X Wang, S Zhao, M Su, L Sun, S Zhang, D Wang…-Biochemical and…, 2016-Elsevier

HFD controls; n = 20) for 6 weeks. After 6 weeks, systolic blood pressure was measured ... HFD controls; n = 20) for 6 weeks. After 6 weeks, systolic blood pressure was measured
IITC Life Science MRBP Blood Pressure System). The using tail cuff plethysmography ( IITC Life Science MRBP Blood Pressure System). The
... mice were deeply anaesthetized with sodium pentobarbital ...

Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress

L Zhang , R Ni, T Cao, D Zheng , S Xiong… - … et Biophysica Acta (BBA …, 2016 - Elsevier S Li, L Zhang , R Ni, T Cao, D Zheng , S Xiong…-… et Biophysica Acta (BBA…, 2016-Elsevier

Animals were acclimated in the environment for 5–10 min after occlusion cuffs and pulse ... Animals were acclimated in the environment for 5–10 min after occlusion cuffs and pulse
MRBP system, IITC Life Science, USA) were placed on the tail. The values of transducers ( MRBP system, IITC Life Science, USA) were placed on the tail. The values of
... at least 10 readings for each mouse were used for blood pressure. 2.4. ...

Influence of P2X receptors on renal medullary circulation is not altered by angiotensin II pretreatment

M Kuczeriszka, L Dobrowolski, A Walkowska…-Pharmacological…, 2016-Elsevier

We confirmed that with this procedure systolic blood pressure (tail-cuff method, ... We confirmed that with this procedure systolic blood pressure (tail-cuff method,
-3R, IITC Inc., Woodland Hills, CA, USA) increased gradually to about 190 mmHg, MRBP -3R, IITC Inc., Woodland Hills, CA, USA) increased gradually to about 190 mmHg,
... compared to about 130 mmHg measured in untreated SD rats. ...

Protective Effects of At1-Receptor Blocker and Ca Antagonist Combination on Renal Function in Salt Loaded Spontaneously Hypertensive Rats / Протективни Ефекти…

K Gjorgjievska, D Zafirov, M Jurhar-Pavlova…-prilozi, 2015-degruyter.com

function tests. SBP was measured by a pletismografic method ( IITC Life Science ... function tests. SBP was measured by a pletismografic method ( IITC Life Science
Blood Pressure System, California, USA) on the rats tail. Body weight was MRBP Blood Pressure System, California, USA) on the rats tail. Body weight was
... measured every second week of treatment. Renal functional ...

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury

E Rübig, J Stypmann, P Van Slyke, DJ Dumont…-Scientific…, 2016-ncbi.nlm.nih.gov

Immediately before the first ultrasound examination, average blood pressure and heart rate ... Immediately before the first ultrasound examination, average blood pressure and heart rate
were measured via tail cuff in each animal (5 measurements) using the mouse blood pressure
MRBP -M01 ( IITC Life science, Woodland Hills, CA, USA). ... system MRBP -M01 ( IITC Life science, Woodland Hills, CA, USA) ...

Changes in protein and gene expression of angiotensin II receptors (AT1 and AT2) in aorta of diabetic and hypertensive rats

R Romero-Nava, JE Rodriguez…-Clinical and…, 2016-Taylor & Francis

Systolic blood pressure (SBP) and heart rate were measured by a non-invasive blood pressure ... Systolic blood pressure (SBP) and heart rate were measured by a non-invasive blood pressure
MRBP Blood Pressure system, IITC , Life Science, Woodland Hills, CA) by tail-cuff method ( MRBP Blood Pressure system, IITC , Life Science, Woodland Hills, CA) by
... photoelectric detection in the rat tail and blood glucose levels were measured with a ...

Low-dose Insulin Treatment Ameliorate Glucose Metabolism in Type 1 Diabetic Rats. J Diabetes Metab 7: 635. doi: 10.4172 / 2155-6156.1000 635 Page 2 of 8…

KA Kadir - 2016 - researchgate.net AXH Ng, SH Ton, KA Kadir-2016-researchgate.net

The blood pressure of rats were measured once every week using the MRBP Mouse and Rat ... The blood pressure of rats were measured once every week using the MRBP Mouse and Rat
IITC Life Sciences, USA). The tail cuff with pulse Tail Cuff Method Blood Pressure System ( IITC Life Sciences, USA). The tail cuff with pulse
... transducer was applied onto the tail of the rat placed in a plastic restrainer. ...

Benefício da Utilização do Novo Alimento Funcional Salgante sem Sódio sobre os Níveis de Pressão Arterial em Animais Hipertensos

, MA Yasuda, L de Paula… - Revista de Pesquisa …, 2015 - pgsskroton.com.br FSM Rodrigues , MA Yasuda, L de Paula…-Revista de Pesquisa…, 2015-pgsskroton.com.br

Os parâmetros foram aferidos através de método não invasivo (indireto) utilizando equipamento ... Os parâmetros foram aferidos através de método não invasivo (indireto) utilizando equipamento
(Mouse Rat Blood Pressure- IITC Life Science) nos dias zero (sem tratamento com NaCl MRBP (Mouse Rat Blood Pressure- IITC Life Science) nos dias zero (sem tratamento com NaCl
... ou Salgante-pó de aspecto cristalino, branco e fino, solúvel em água, com odor ...

 

pressure -induced vasodilation that protects against pressure ulcers Asic3 is a neuronal mechanosensor for pressure -induced vasodilation that protects against pressure ulcers

E Lingueglia , D Sigaudo-Roussel… - Nature medicine, 2012 - nature .com B Fromy, E Lingueglia , D Sigaudo-Roussel…-Nature medicine, 2012- nature .com

The experimental protocol was approved by the scientific and ethics committees of the University ... The experimental protocol was approved by the scientific and ethics committees of the University
... Claude Bernard Lyon 1, France (no. ...   Blood   was monitored noninvasively throughout pressure was monitored noninvasively throughout
system ( IITC the experiment using a tail cuff system ( IITC   / Life INC / Life   Instruments). .. Science Instruments) ...

Nature Medicine , 五年影响因子高达 27.887 " Nature Medicine " , five-year impact factor up to 27.887

Salt--sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

Nature medicine , 1999 - nature.com CRJ Kennedy, Y Zhang, S Brandon, Y Guan… -Nature medicine , 1999-nature.com

Mouse blood ... Mouse blood   was measured using an IITC pressure was measured using an IITC   Life   Model 27 cuff pump with a Science Model 27 cuff pump with a
blood Model 179 blood   analyzer. Pressure was measured at 30 °C and was initiated as pressure analyzer. Pressure was measured at 30 ° C and was initiated as
... cuffs were inflated to 200 mm Hg and deflated at a rate of 3 mm Hg / sec. ...


Chronic β-adrenergic stimulation induces myocardial proinflammatory cytokine expression

Circulation, 2000 - Am Heart Assoc DR Murray, SD Prabhu, B Chandrasekar- Circulation, 2000-Am Heart Assoc

System–Audie Murphy Division, San Antonio, Tex (DRM, BC), and the University of Louisville ... System--Audie Murphy Division, San Antonio, Tex (DRM, BC), and the University of Louisville
Sciences Center, Louisville ... 1 · d −1 , n=8) or saline (n=7). After anesthesia, measures Health Sciences Center, Louisville ... 1 · d −1, n = 8) or saline (n = 7). After anesthesia, measures
blood of body weight, blood   , and heart rate (tail cuff, IITC pressure , and heart rate (tail cuff, IITC   Life   model 29 ... Science model 29 ...

15.202 (2013) , 该杂志 2011 年在 CARDIAC & CARDIOVASCULAR SYSTEMS (心血管) 同类期刊中的影响因子排名第 1 位。 Circulation's latest impact factor is 15.202 (2013) . In 2011 , the magazine ranked first in the impact factor of similar journals in CARDIAC & CARDIOVASCULAR SYSTEMS (cardiovascular) .

Endogenous Ligand of α1 Sodium Pump, Marinobufagenin, Is a Novel Mediator of Sodium Chloride--Dependent Hypertension

Circulation , 2002 - Am Heart Assoc OV Fedorova, MI Talan, NI Agalakova, EG Lakatta…-Circulation , 2002-Am Heart Assoc

Systolic BP (SBP) was measured weekly by tail-cuff plethysmography ( IITC model 31, IITC ... Systolic BP (SBP) was measured weekly by tail-cuff plethysmography ( IITC model 31, IITC   Life
). ... 1969; 1 (suppl 24, 25): 21–33. ↵ Blaustein MP. Sodium ions, calcium ions, blood Science ). ... 1969; 1 (suppl 24, 25): 21–33. ↵ Blaustein MP. Sodium ions, calcium ions, blood
regulation and hypertension: a reassessment and a hypothesis. Am J Physiol. ... pressure regulation and hypertension: a reassessment and a hypothesis. Am J Physiol. ...

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